Kinetochores hang on for the ride
نویسندگان
چکیده
منابع مشابه
Kinetochores hang on for the ride
C hromosomes are shunted around the cell during mitosis to align at the metaphase plate and then segregate to the spindle poles. These movements are driven by dynamic microtubules, which polymerize and disassemble to pull the chromosomes into position. Chromosomes grab microtubules via their kinetochores, but how do they maintain their grip as the microtubules turn over? “It’s pretty amazing,” ...
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The multiple functions of kinetochores are reflected in their complex composition, with over a hundred different proteins, which self-associate in several functional subcomplexes. Most of these kinetochore proteins were identified over the last 10-12 years using a combination of genetic, cell biological, biochemical, and bioinformatic approaches in various model organisms. The key challenge sin...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2010
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1894if